Potency of Phytochemicals from Guava (Psidium guajava) Seeds against Escherichia coli to Cure Diarrhoea: An in silico Analysis

Machine learning to deep learning is the enduring upgrading in the pharmaceutical research field. Phytochemicals from Psidium guajava plant extract are traditionally used to cure Diarrhoea. The causative agent of the disease is Escherichia coli. To identify the secondary metabolites (ligand) which is the main responsive compound that have the capacity to inhibit the growth of microorganism was carried bymolecular docking method “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that Heptadecanoic acid can effectively deactivate the shikimate dehydrogenase enzyme thereby interrupting the life cycle of the organism

Eclipta alba Derived Phytochemicals against Jaundice

Phytochemicals otherwise known assecondary metabolites means the small organic molecules that are not essential for growth, development and reproduction but can protect from various diseases. Infact these phytochemicals are the key source of medicine. Secondary metabolites from Eclipta alba plant extract are traditionally used to cure Jaundice which is caused by Leptospira interrogans. The curative property of Eclipta alba against Leptospira interrogans was proved by molecular docking method in “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” recommended that pentadecan, heptadecane, 6,10,14-trimethyl-2-petadecanone can successfully deactivate the thioredoxin-disulfide reductase enzyme thereby disrupting the cellular function as well as the lifecycle of causative organism